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APOE Alleles’ Association with Cognitive Function Differs across Hispanic/Latino Groups and Genetic Ancestry in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL) – Carolina Center for Population Aging and Health

APOE Alleles’ Association with Cognitive Function Differs across Hispanic/Latino Groups and Genetic Ancestry in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL)

Citation

Granot-Hershkovitz, Einat; Tarraf, Wassim; Kurniansyah, Nuzulul; Daviglus, Martha L.; Isasi, Carmen R.; Kaplan, Robert C.; Lamar, Melissa; Perreira, Krista M.; Wassertheil-Smoller, Sylvia; & Stickel, Ariana M., et al. (2021). APOE Alleles' Association with Cognitive Function Differs across Hispanic/Latino Groups and Genetic Ancestry in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL). Alzheimer's & Dementia, 17(3), 466-474. PMCID: PMC8016734

Abstract

INTRODUCTION: Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects.
METHODS: We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations.
RESULTS: APOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P-value = 0.03), with the strongest association in Cubans (OR = 1.46, P-value = 0.007). APOE-ε2 was associated with decreased risk of MCI (OR = 0.37, P-value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline.
DISCUSSION: Results suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry.

URL

http://dx.doi.org/10.1002/alz.12205

Reference Type

Journal Article

Article Type

Regular

Year Published

2021

Journal Title

Alzheimer's & Dementia

Author(s)

Granot-Hershkovitz, Einat
Tarraf, Wassim
Kurniansyah, Nuzulul
Daviglus, Martha L.
Isasi, Carmen R.
Kaplan, Robert C.
Lamar, Melissa
Perreira, Krista M.
Wassertheil-Smoller, Sylvia
Stickel, Ariana M.
Thyagarajan, Bharat
Zeng, Donglin
Fornage, Myriam
DeCarli, Charles S.
González, Hector M.
Sofer, Tamar

PMCID

PMC8016734

Data Set/Study

Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Continent/Country

United States of America

State

Nonspecific

Race/Ethnicity

Hispanic/Latinx