Citation
Yao, Yao; Liu, Linxin; Guo, Guang; Zeng, Yi; & Ji, John S. (2021). Interaction of Sirtuin 1 (SIRT1) Candidate Longevity Gene and Particulate Matter (PM2.5) on All-Cause Mortality: A Longitudinal Cohort Study in China. Environmental Health, 20(1), 25. PMCID: PMC7958462Abstract
BACKGROUND: The SIRT1 gene was associated with the lifespan in several organisms through inflammatory and oxidative stress pathways. Long-term air particulate matter (PM) is detrimental to health through the same pathways.METHODS: We used the Chinese Longitudinal Healthy Longevity Survey (CLHLS) to investigate whether there is a gene-environment (G × E) interaction of SIRT1 and air pollution on mortality in an older cohort in China. Among 7083 participants with a mean age of 81.1 years, we genotyped nine SIRT1 alleles for each participant and assessed PM(2.5) concentration using 3-year average concentrations around each participant's residence. We used Cox-proportional hazards models to estimate the independent and joint effects of SIRT1 polymorphisms and PM(2.5) exposure on all-cause mortality, adjusting for a set of confounders.
RESULTS: There were 2843 deaths over 42,852 person-years. The mortality hazard ratio (HR) and 95% confidence interval (CI) for each 10
URL
http://dx.doi.org/10.1186/s12940-021-00718-xReference Type
Journal ArticleYear Published
2021Journal Title
Environmental HealthAuthor(s)
Yao, YaoLiu, Linxin
Guo, Guang
Zeng, Yi
Ji, John S.