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Citation

Kamath, Vidyulata; Senjem, Matthew L.; Spychalla, Anthony J.; Chen, Honglei; Palta, Priya; Mosley, Thomas H., Jr.; Windham, B. Gwen; Griswold, Michael; Knopman, David S.; & Gottesman, Rebecca F., et al. (2022). The Neuroanatomic Correlates of Olfactory Identification Impairment in Healthy Older Adults and in Persons with Mild Cognitive Impairment. J Alzheimers Dis, 89(1), 233-245. PMCID: PMC10134400

Abstract

BACKGROUND: Olfactory identification (OI) impairment appears early in the course of Alzheimer's disease dementia (AD), prior to detectable cognitive impairment. However, the neuroanatomical correlates of impaired OI in cognitively normal older adults (CN) and persons with mild cognitive impairment (MCI) are not fully understood.
OBJECTIVE: We examined the neuroanatomic correlates of OI impairment in older adults from the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).
METHODS: Our sample included 1,600 older adults without dementia who completed clinical assessment and structural brain imaging from 2011 to 2013. We characterized OI impairment using the 12-item Sniffin' Sticks odor identification test (score

URL

http://dx.doi.org/10.3233/jad-220228

Reference Type

Journal Article

Year Published

2022

Journal Title

J Alzheimers Dis

Author(s)

Kamath, Vidyulata
Senjem, Matthew L.
Spychalla, Anthony J.
Chen, Honglei
Palta, Priya
Mosley, Thomas H., Jr.
Windham, B. Gwen
Griswold, Michael
Knopman, David S.
Gottesman, Rebecca F.
Jack, Clifford R., Jr.
Sharrett, A. Richey
Schneider, Andrea L. C.

PMCID

PMC10134400