Citation
Martin, Chantel L.; Ward-Caviness, Cavin K.; Dhingra, Radhika; Zikry, Tarek M.; Galea, Sandro; Wildman, Derek E.; Koenen, Karestan C.; Uddin, Monica; & Aiello, Allison E. (2021). Neighborhood Environment, Social Cohesion, and Epigenetic Aging. Aging, 13(6), 7883-7899. PMCID: PMC8034890Abstract
Living in adverse neighborhood environments has been linked to risk of aging-related diseases and mortality; however, the biological mechanisms explaining this observation remain poorly understood. DNA methylation (DNAm), a proposed mechanism and biomarker of biological aging responsive to environmental stressors, offers promising insight into potential molecular pathways. We examined associations between three neighborhood social environment measures (poverty, quality, and social cohesion) and three epigenetic clocks (Horvath, Hannum, and PhenoAge) using data from the Detroit Neighborhood Health Study (n=158). Using linear regression models, we evaluated associations in the total sample and stratified by sex and social cohesion. Neighborhood quality was associated with accelerated DNAm aging for Horvath age acceleration (URL
http://dx.doi.org/10.18632/aging.202814Reference Type
Journal ArticleYear Published
2021Journal Title
AgingAuthor(s)
Martin, Chantel L.Ward-Caviness, Cavin K.
Dhingra, Radhika
Zikry, Tarek M.
Galea, Sandro
Wildman, Derek E.
Koenen, Karestan C.
Uddin, Monica
Aiello, Allison E.
Article Type
RegularPMCID
PMC8034890Data Set/Study
Detroit Neighborhood Health Study (DNHS)Continent/Country
United States of AmericaState
MichiganORCiD
Martin, C. - 0000-0003-1907-0810Aiello - 0000-0001-7029-2537