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Citation

Prado, Carla M.; Batsis, John A.; Donini, Lorenzo M.; Gonzalez, M. Cristina; & Siervo, Mario (Online ahead of print). Sarcopenic Obesity in Older Adults: A Clinical Overview. Nature Reviews. Endocrinology.

Abstract

Sarcopenic obesity is characterized by a concurrent decline in muscle mass and function, along with increased adipose tissue. Sarcopenic obesity is a growing concern in older adults owing to significant health consequences, including implications for mortality, comorbidities and risk of developing geriatric syndromes. A 2022 consensus statement established a new definition and diagnostic criteria for sarcopenic obesity. The pathophysiology of this condition involves a complex interplay between muscle, adipose tissue, hormonal changes, inflammation, oxidative stress and lifestyle factors, among others. Sarcopenic obesity is treated with a range of management approaches, such as lifestyle interventions, exercise, nutrition and medical therapies. Emerging therapies that were developed for treating other conditions may be relevant to sarcopenic obesity, including novel pharmacological agents and personalized approaches such as precision medicine. In this Review, we synthesize the current knowledge of the clinical importance of sarcopenic obesity, its assessment and diagnosis, along with current and emerging management strategies.

URL

http://dx.doi.org/10.1038/s41574-023-00943-z

Reference Type

Journal Article

Year Published

Online ahead of print

Journal Title

Nature Reviews. Endocrinology

Author(s)

Prado, Carla M.
Batsis, John A.
Donini, Lorenzo M.
Gonzalez, M. Cristina
Siervo, Mario

Article Type

Regular

Continent/Country

United States

State

Nonspecific

ORCiD

Batis - 0000-0002-2823-6651