Citation
Heilbronner, Urs; Papiol, Sergi; Budde, Monika; Andlauer, Till F. M.; Strohmaier, Jana; Streit, Fabian; Frank, Josef; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; & Witt, Stephanie H., et al. (2021). “The Heidelberg Five” Personality Dimensions: Genome-Wide Associations, Polygenic Risk for Neuroticism, and Psychopathology 20 Years after Assessment. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 186(2), 77-89.Abstract
HeiDE is a longitudinal population-based study that started in the 1990s and, at baseline, assessed an array of health-related personality questionnaires in 5133 individuals. Five latent personality dimensions (The Heidelberg Five) were identified and interpreted as Emotional Lability (ELAB), Lack of Behavioral Control (LBCN), Type A Behavior (TYAB), Locus of Control over Disease (LOCC), and Psychoticism (PSYC). At follow-up, 3268 HeiDE participants (post-QC) were genotyped on single nucleotide polymorphism (SNP) arrays. To further characterize The Heidelberg Five, we analyzed genomic underpinnings, their relations to the genetic basis of the Big Five trait Neuroticism, and longitudinal associations with psychiatric symptoms at follow-up. SNP-based heritability was significant for ELAB (34%) and LBCN (29%). A genome-wide association study for each personality dimension was conducted; only the phenotype PSYC yielded a genome-wide significant finding (p < 5 × 10URL
https://doi.org/10.1002/ajmg.b.32837Reference Type
Journal ArticleYear Published
2021Journal Title
American Journal of Medical Genetics Part B: Neuropsychiatric GeneticsAuthor(s)
Heilbronner, UrsPapiol, Sergi
Budde, Monika
Andlauer, Till F. M.
Strohmaier, Jana
Streit, Fabian
Frank, Josef
Degenhardt, Franziska
Heilmann-Heimbach, Stefanie
Witt, Stephanie H.
Forstner, Andreas J.
Loerbroks, Adrian
Amelang, Manfred
Stürmer, Til
Müller-Myhsok, Bertram
Nöthen, Markus M.
Rietschel, Marcella
Schulze, Thomas G.