Citation
Nguyen, Steve; LaCroix, Andrea Z.; Hayden, Kathleen M.; Di, Chongzhi; Palta, Priya; Stefanick, Marcia L.; Manson, JoAnn E.; Rapp, Stephen R.; LaMonte, Michael J.; & Bellettiere, John (2023). Accelerometer-Measured Physical Activity and Sitting with Incident Mild Cognitive Impairment or Probable Dementia among Older Women. Alzheimers Dement, 19(7), 3041-3054. PMCID: PMC10366337Abstract
INTRODUCTION: Physical activity (PA) is prospectively inversely associated with dementia risk, but few studies examined accelerometer measures of PA and sitting with rigorously-adjudicated mild cognitive impairment (MCI) and dementia risk.METHODS: We examined the associations of accelerometer measures (PA and sitting) with incident MCI/probable dementia in the Women's Health Initiative (n = 1277; mean age = 82 ± 6 years).
RESULTS: Over a median follow-up of 4.2 years, 267 MCI/probable dementia cases were identified. Adjusted Cox regression HRs (95% CI) across moderate-to-vigorous PA (MVPA) min/d quartiles were 1.00 (reference), 1.28 (0.90 to 1.81), 0.79 (0.53 to 1.17), and 0.69 (0.45 to 1.06); P-trend = 0.01. Adjusted HRs (95% CI) across steps/d quartiles were 1.00 (reference), 0.73 (0.51 to 1.03), 0.64 (0.43 to 0.94), and 0.38 (0.23 to 0.61); P-trend < 0.001. The HR (95% CI) for each 1-SD increment in MVPA (31 min/d) and steps/d (1865) were 0.79 (0.67 to 0.94) and 0.67 (0.54 to 0.82), respectively. Sitting was not associated with MCI/probable dementia.
DISCUSSION: Findings suggest
URL
http://dx.doi.org/10.1002/alz.12908Reference Type
Journal ArticleYear Published
2023Journal Title
Alzheimers DementAuthor(s)
Nguyen, SteveLaCroix, Andrea Z.
Hayden, Kathleen M.
Di, Chongzhi
Palta, Priya
Stefanick, Marcia L.
Manson, JoAnn E.
Rapp, Stephen R.
LaMonte, Michael J.
Bellettiere, John