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Citation

Nguyen, Steve; LaCroix, Andrea Z.; Hayden, Kathleen M.; Di, Chongzhi; Palta, Priya; Stefanick, Marcia L.; Manson, JoAnn E.; Rapp, Stephen R.; LaMonte, Michael J.; & Bellettiere, John (2023). Accelerometer-Measured Physical Activity and Sitting with Incident Mild Cognitive Impairment or Probable Dementia among Older Women. Alzheimers Dement, 19(7), 3041-3054. PMCID: PMC10366337

Abstract

INTRODUCTION: Physical activity (PA) is prospectively inversely associated with dementia risk, but few studies examined accelerometer measures of PA and sitting with rigorously-adjudicated mild cognitive impairment (MCI) and dementia risk.
METHODS: We examined the associations of accelerometer measures (PA and sitting) with incident MCI/probable dementia in the Women's Health Initiative (n = 1277; mean age = 82 ± 6 years).
RESULTS: Over a median follow-up of 4.2 years, 267 MCI/probable dementia cases were identified. Adjusted Cox regression HRs (95% CI) across moderate-to-vigorous PA (MVPA) min/d quartiles were 1.00 (reference), 1.28 (0.90 to 1.81), 0.79 (0.53 to 1.17), and 0.69 (0.45 to 1.06); P-trend = 0.01. Adjusted HRs (95% CI) across steps/d quartiles were 1.00 (reference), 0.73 (0.51 to 1.03), 0.64 (0.43 to 0.94), and 0.38 (0.23 to 0.61); P-trend < 0.001. The HR (95% CI) for each 1-SD increment in MVPA (31 min/d) and steps/d (1865) were 0.79 (0.67 to 0.94) and 0.67 (0.54 to 0.82), respectively. Sitting was not associated with MCI/probable dementia.
DISCUSSION: Findings suggest

URL

http://dx.doi.org/10.1002/alz.12908

Reference Type

Journal Article

Year Published

2023

Journal Title

Alzheimers Dement

Author(s)

Nguyen, Steve
LaCroix, Andrea Z.
Hayden, Kathleen M.
Di, Chongzhi
Palta, Priya
Stefanick, Marcia L.
Manson, JoAnn E.
Rapp, Stephen R.
LaMonte, Michael J.
Bellettiere, John

PMCID

PMC10366337